マイクロサンプリング法のマウスの生体及び毒性評価への影響検討

高橋 一彰; 友成 由紀; 村田 英治; 中井 恵子; 山本 大; 岡村 隆之; 岩井 淳; 中川 宗洋

doi:10.14869/toxpt.48.1.0_P-144

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-144

DOI https://doi.org/10.14869/toxpt.48.1.0_P-144

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Host: The Japanese Society of Toxicology

e-Poster

Effect of microsampling method on organisms and toxicological evaluation of mice

*Kazuaki TAKAHASHI, Yuki TOMONARI, Eiji MURATA, Keiko NAKAI, Dai YAMAMOTO, Takayuki OKAMURA, Atsushi IWAI, Munehiro NAKAGAWA

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Abstract

We investigated the effects of the microsampling (MS) method on organisms and toxicity assessment of mice. Firstly, Crl:CD1(ICR) mice with their blood samples collected by the MS method over time were compared with those without blood collection. Secondly, Crl:CD1(ICR) mice with blood samples collected by the MS method after administration of 1-naphthyl isothiocyanate (ANIT) were compared with those without blood collection. The results showed that although the MS method affected the hematological parameters of the mice, it did not affect the evaluation of acute hepatotoxicity caused by ANIT.

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