Next Generation Safety Assessment of Cosmetics -Read-across with 200 million chemicals-

Abstract

Comprehensive read-across was investigated using existing large-scale chemical information as the next generation of cosmetic safety assessment without animal testing.

2,6-di-t-butyl-4-ethylphenol, which is hepatotoxic, was selected as the model compound. Comprehensive read-across was conducted, and satisfactory prediction results were obtained. On the other hand, toxicity results may differ among compounds with highly similar chemical structures, suggesting that phenotype-based read-across is necessary in addition to chemical structure-based read-across.