Next Generation Safety Assessment of Cosmetics - Comprehensive Read-across in Skin Sensitization Assessment -

Abstract

Read-across using existing large-scale chemical information is an essential method in the next-generation safety assessment of cosmetics without animal testing. In this study, we evaluated skin sensitization intensity in LLNA using chemical-structure-based comprehensive read-across. The results showed that most compounds (including negative ones) could be predicted to a satisfactory degree. However, read-across with gene-expression-response similarities might be required for compounds which are highly similar but have significantly different sensitization intensities.