Next Generation Safety Assessment of Cosmetics -Potential of Transcriptome Analysis in Cardiac Toxicity Prediction-

Abstract

In this study, we focused on transcriptome analysis as a technique for evaluating the cardiac toxicity potential of chemical substances. The similarity of the gene expression pattern with Terfenadine is defined as the cosine similarity. As a result, among 177 drugs, Astemizole and Prenylamine (withdrawn from market due to cardiotoxicity) were included in the top 5 drugs with similar gene expression patterns to Terfenadine. The cosine similarity also showed a good correlation with the risk classification of human cardiotoxicity.