Investigation of membrane permeability and metabolism of compounds in food using human iPS cell-derived small intestinal epithelial cells

Abstract

To investigate the membrane permeability and drug metabolic activities of human iPS cell-derived small intestinal epithelial cells, we compared these characteristics with Caco-2 cells or human primary enterocytes. Human iPS cell-derived intestinal epithelial cells showed a better correlation between intestinal absorption rates and membrane permeation rates than Caco-2 cells and showed close metabolic rates with human primary enterocytes for UGT substrates. Therefore, human iPS cell-derived intestinal epithelial cells might be a useful tool for predicting human intestinal absorption.