Investigation of the mechanisms underlying hepatocarcinogenesis of 1,3-dichloro-2-propanol using gpt delta transgenic rats

Abstract

1,3-Dichloro-2-propanol (1,3-DCP), a food contaminant, is carcinogenic in rats. To understand the mechanisms of 1,3-DCP-induced hepatocarcinogenesis, we examined histopathology, in vivo mutagenicity and preneoplastic lesions in the livers of gpt delta rats treated with 1,3-DCP under carcinogenic conditions. gpt mutant frequencies were significantly increased in 1,3-DCP-treated rats, suggesting the involvement of genotoxic mechanisms in hepatocarcinogenecity of 1,3-DCP. On the other hand, lack of increases in GST-P+ foci was observed and will be discussed along with further investigations.