Setting of Acceptable Surface Limit (ASL) and Occupational Exposure Band (OEB) for Skin Sensitizers using EC1.6 values derived from LLNA:BrdU-ELISA

Abstract

The setting of health-based exposure limit (HBEL) for chemicals is important for avoidance of cross-contamination and for occupational safety. In this study, we tried to set Acceptable Surface Limit (ASL) and Occupational Exposure Band (OEB) for skin sensitizers based on EC1.6 derived from LLNA:BrdU-ELISA. Adjustment factors for extrapolating EC1.6 to human risk were set then quantitative ASL and OEB were proposed. Chemicals with ASL less than 1 mg/100 cm² were consistent with GHS 1A chemicals, suggesting our method enables setting HBEL corresponding to the international hazard classification.