Development of an Automated Target Knowledge Review Application to Accelerate Target Safety Evaluations

Abstract

Pfizer’s Drug Safety Group has been systematically evaluating drug targets for safety risks in the form of Target Knowledge Reviews (TKRs), requiring time-consuming, manual curation of target data. To allocate more time for risk assessment, we have developed Automated Target Knowledge Reviews (AutoTKR) application. AutoTKR automates information curation including orthologs/similar targets cross-species, target tissue expression, genetics, and compounds, and formats for into a report. This application opens up more time for deeper dives into target knowledge and greater insights.