Time-Course evaluation of hepatomegaly in mice using micro-CT and the aspect interfering toxicological interpretation

Abstract

Micro-computed tomography (micro-CT) is an imaging modality that enable us to non-invasively obtain 3D images of organs in laboratory animals. By using micro-CT, internal organs can be monitored repeatedly, which leads to more precise evaluation and reduction in the number of animals used. In this study, we evaluated time-course of chemically-induced hepatomegaly in mice using micro-CT.

The liver volume calculated from CT images was highly correlated to the liver weight. Therefore, it was considered that CT imaging can be a useful tool for evaluating the time-course of hepatomegaly.