マウス食餌性非アルコール性脂肪肝炎（NASH）モデルの線維化におけるSox9の関与に関する研究

中根 冴; 煙山 紀子; 阿部 有加里; 結城 恵美; 宇野 絹子; 小川 秀治; 佐野 龍平; 渡辺 厚; 高須 伸二; 梅村 隆志; 美谷島 克宏; 中江 大

doi:10.14869/toxpt.48.1.0_P-50S

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-50S

DOI https://doi.org/10.14869/toxpt.48.1.0_P-50S

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Involvement of Sox9 in liver fibrosis of non-alcoholic steatohepatitis (NASH) dietarily induced in mice

*Sae NAKANE, Noriko KEMURIYAMA, Akari ABE, Megumi YUKI, Kinuko UNO, Syuji OGAWA, Ryuhei SANO, Atushi WATANABE, Shinji TAKASU, Takashi UMEMURA, Katuhiro MIYAJIMA, Dai NAKAE

Author information

*Sae NAKANE
Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture
Noriko KEMURIYAMA
Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture
Akari ABE
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Megumi YUKI
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Advantec Co.,Ltd. Pathology Department
Kinuko UNO
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
Syuji OGAWA
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
Ryuhei SANO
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
Atushi WATANABE
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
Shinji TAKASU
Division of Pathology, National Institute of Health Science
Takashi UMEMURA
Division of Pathology, National Institute of Health Science
Faculty of Animal Health Techolorgy, Yamazaki University of Animal Health Techology
Katuhiro MIYAJIMA
Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
Dai NAKAE
Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture

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Abstract

The present study aimed to clarify whether a bile ductular reaction induces liver fibrosis in the dietarily induced mouse NASH model, using the expression of SRY-box9 (Sox9) as a biomarker. In the liver of mice fed a special CDAHFD-0.1 diet for 14 days, steatosis became remarkable with slight fibrosis, and the extra-bile duct Sox9 expression was observed. At the end of week 13, fibrosis became prominent, and the Sox9 expression was marked and diffuse. In conclusion, the Sox9 expression may not be a consequence of NASH-derived liver fibrosis, but involved in its development and progression.

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