非アルコール性脂肪性肝疾患関連初期発がんモデルの肝前がん病変におけるERファジーの解析

魚本 涼加; 清水 紗織; 武居 圭祐; 前田 夏乃; 小林 美央; 大島 可南美; 原 絵美香; 曾 雯; 渋谷 淳; 吉田 敏則

doi:10.14869/toxpt.48.1.0_P-51S

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-51S

DOI https://doi.org/10.14869/toxpt.48.1.0_P-51S

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Analysis of ERphagy in the preneoplastic lesions in nonalcoholic fatty liver disease-related early hepatocarcinogenesis model

*Suzuka UOMOTO, Saori SHIMIZU, Keisuke TAKESUE, Natsuno MAEDA, Mio KOBAYASHI, Kanami OSHIMA, Emika HARA, Wen ZENG, Makoto SHIBUTANI, Toshinori YOSHIDA

Author information

*Suzuka UOMOTO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Saori SHIMIZU
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Keisuke TAKESUE
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Natsuno MAEDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Mio KOBAYASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Kanami OSHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Emika HARA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Wen ZENG
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

We determined the role of selective autophagy of endoplasmic reticulum (ERphagy) in the preneoplastic lesions in steatosis-related early hepatocarcinogenesis model of rats. The increase of the preneoplastic lesions in the HFD or PB groups might be related to inhibition of ERphagy as shown by increased expression of LC3B and FAM134B, and the decrease of the lesions in the HFD-PB groups might be caused by the induction of ERphagy.

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