Host: The Japanese Society of Toxicology
Antibiotics (ABXs) are one of the major drugs which induce liver injury frequently, so, it is important to clarify the mechanism of ABXs-induced liver injury. We focused the alteration of bile acid composition by ABXs treatment. Bile acids are important to maintain vital functions, but dysregulation of bile acid homeostasis increases the risk of developing liver injury. Among them, ABXs dramatically change bile acids composition, especially increasing conjugated primary bile acid level. Present study constructed the mice model and investigated the relation liver injury and alteration of bile acid homeostasis using flucloxacillin.
