２型糖尿病モデルdb/db及びKK-Ayマウスにおける高脂肪食給餌による肝臓への影響

万代 康平; 美谷島 克宏; 北村 紗也夏; 山口 彩音; 宇野 絹子; 黒木 楓子; 西田 芽衣; 白坂 航大; 筒井 誉大; 武呂 大和; 杉本 実紀; 煙山 紀子; 篠原 雅実; 笹瀬 智彦; 太田 毅; 中江 大

doi:10.14869/toxpt.48.1.0_P-53S

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-53S

DOI https://doi.org/10.14869/toxpt.48.1.0_P-53S

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Effect of high fat diet on liver in db/db and KK-Ay mice

*Kouhei MANDAI, Katsuhiro MIYAJIMA, Sayaka KITAMURA, Ayane YAMAGUCHI, Kinuko UNO, Fuko KUROKI, Mei NISHIDA, Koudai SHIRASAKA, Takahiro TSUTSUI, Yamato MURO, Miki SUGIMOTO, Noriko KEMURIYAMA, Masami SHINOHARA, Tomohiko SASASE, Takeshi OHTA, Dai NAKAE

Author information

*Kouhei MANDAI
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Graduate School of Tokyo University of Agriculture
Katsuhiro MIYAJIMA
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Graduate School of Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Sayaka KITAMURA
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
Ayane YAMAGUCHI
Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
Kinuko UNO
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University
Fuko KUROKI
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Mei NISHIDA
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Koudai SHIRASAKA
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Takahiro TSUTSUI
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Yamato MURO
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Miki SUGIMOTO
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Noriko KEMURIYAMA
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
Masami SHINOHARA
Tokyo Animal & Diet Dept. CLEA Japan, Inc.
Tomohiko SASASE
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Takeshi OHTA
Tokyo Animal & Diet Dept. CLEA Japan, Inc.
Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University
Dai NAKAE
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Graduate School of Tokyo University of Agriculture
Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture
Department of Food and Nutrition Science, Graduate School of Agriculture, Tokyo University

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

To investigate effect of high fat diet on liver in obese type 2 diabetes model, 5-week-old female db/db and KK-Ay mice were fed CE-2 (Basal Diet), Quick Fat (QF:High fat diet) or Western Diet (WD: QF+2% cholesterol added) ad libitum for 8 weeks. C57BL/6J mice were fed by the same diets as a physiological control. At 13-week-old of age, mice were dissected, collected the blood and organ and were performed various analysis.

In both diabetic strains, the induction of fatty liver by QF was more advanced in KK-Ay. In addition, WD was induced liver fibrosis, and it was more prominent in db/db mice.

Corresponding author

Register with J-STAGE for free!