Historical control data for serum thyroid hormone (T3, T4) and thyroid-stimulating hormone (TSH) levels

Abstract

Assessment of thyroid and thyroid-stimulating hormones (T4, T3, TSH) was added to the OECD test guideline Nos. 408, 414, 421, 422, and 443 to improve detection of potential endocrine activity. We obtained historical control data for these hormones using Crl:CD(SD) rats. The coefficients of variation of values obtained were less than 25% for T3 and T4 and less than 35% for TSH, which met the criteria specified in the guidelines. These data were considered useful to assess changes in hormone levels by chemical exposure. At the venue, the details of the methods and the results are presented.