Host: The Japanese Society of Toxicology
Gingival Hyperplasia (GH) is a side effect after drug administration in the oral tissue. GH has been reported to be caused by taking antihypertensive drug. In this study, we investigated the physiological significance of Metallothionein (MT) in gingival cells after treatment with Amlodipine, it is known as an antihypertensive agent. Cd or Amlodipine treatment induced the MT expression. Amlodipine is known to be involved in the onset of GH, the MT in gingival cells could work as a multifunctional protein induced during cell proliferation as well as a biological defense reaction to heavy metals.
