Detailed investigation of bone marrow toxicity induced by anticancer drugs in various animals

Abstract

Chemotherapy induced neutropenia and febrile neutropenia are frequent side effects in anticancer drug treatment, and result in reduces in therapeutic effects. To establish TK / TD model which provide important information to patients, detailed data on the effects of Docetaxel, Paclitaxel, Irinotecan, or Topotecan on bone marrow in various animals (rats, mice, dogs, or monkeys) were evaluated. Comparative assessment of the differences in bone marrow toxicity among animals or drugs will be presented.