Collection of basic data for introduction of microchips for individual identification in mouse toxicity studies

Abstract

Animal identification methods are ideally non-invasive, simple, and highly legible. Microchips (MCs) are one such method but are rarely used in toxicity studies in Japan. In this study, we implanted MCs in 30 Crl:CD1 (ICR) mice and investigated MC readability and effects for 13 weeks.

MCs were readable throughout the study. No abnormalities were observed in any examination parameter except for very slight and focal changes in the subcutaneous tissue around the MC implantation site in histopathology. Therefore, we judged that MCs can be used in mice toxicity studies for up to 13 weeks.