The incidence of sudden deaths in the control group in toxicity studies in SD rats

Abstract

We investigated the sudden deaths which occurred up to 6 month of examination (31 weeks of age) in total 156 of toxicity/carcinogenicity studies in Crl:CD(SD) rats between 2009 and 2019 in our facility. Sudden deaths occurred in 10 out of 3377 males and 1 out of 3252 females. Pathological examination revealed no life-threatening finding and the cause of death was unclear, though 2 males showed convulsion before the death. The incidence of sudden deaths tended to increase with the age of animals. In this meeting, we will update the data of recent years.