Combined effects of maternal exposure to fungicides in F₁-generation mice: Fixed-dose study of imazalil

Abstract

Imazalil (IMZ) and thiabendazole (TBZ) were given in the diet at levels of 0%/0%, 0.006%/0.006%, 0.006%/0.018%, and 0.006%/0.054% during the gestation and lactation periods. The time required of olfactory orientation was accelerated in higher-dose groups in female offspring on PND 14 in a dose-related manner. In the exploratory behavior, the frequency of mice with urination increased in a dose-related manner in male offspring. In spontaneous behavior, the longitudinal pattern of total distance was not parallel (different pattern) among the control and IMZ/TBZ treatment groups in adult males.