Host: The Japanese Society of Toxicology
Acetyl-CoA carboxylase (ACC) catalyzes the first step of de novo lipogenesis. PF-05175157, a systemically acting dual ACC1/2 inhibitor, caused developmental toxicity in embryo-fetal development studies in both the rat and rabbit. Additional studies in rat whole embryo culture, mouse embryonic stem cells, and zebrafish developmental toxicity assay were conducted to evaluate the utility of these in vitro assays in detecting ACC-induced developmental toxicity. This work demonstrates that a battery of in vitro assays to screen compounds for developmental toxicity is more informative than any single assay.
