エタノールの28日間反復投与によるラット海馬神経新生における神経幹細胞および神経前駆細胞の減少とシナプス可塑性の抑制

高橋 康徳; 清水 沙織; 前田 夏乃; 岡野 拡; 高嶋 和巳; 尾城 椋太; Qian TANG; 菊地 聡美; 吉田 敏則; 渋谷 淳

doi:10.14869/toxpt.48.1.0_P-89E

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-89E

DOI https://doi.org/10.14869/toxpt.48.1.0_P-89E

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Twenty-eight-day repeated oral doses of ethanol decrease neural stem cells to suppress differentiation to neural progenitor cells as well as reduced synaptic plasticity in adult hippocampal neurogenesis of postpubertal rats

*Yasunori TAKAHASHI, Saori SHIMIZU, Natsuno MAEDA, Hiromu OKANO, Kazumi TAKASHIMA, Ryota OJIRO, Qian TANG, Satomi KIKUCHI, Toshinori YOSHIDA, Makoto SHIBUTANI

Author information

*Yasunori TAKAHASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Saori SHIMIZU
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Natsuno MAEDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Hiromu OKANO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Kazumi TAKASHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Ryota OJIRO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Qian TANG
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Satomi KIKUCHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

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Abstract

This study examined 28-day repeated oral exposure effect of ethanol (EtOH) on hippocampal neurogenesis in rats. Five-week-old male SD rats were administered 0, 10 or 16% (v/v) EtOH via drinking water for 28 days. EtOH at the high dose decreased the number of type-1 and type-2a cells in the subgranular zone, increased PVALB+ interneurons in the dentate gyrus hilus, and decreased c-FOS+ granule cells, suggesting a prevention of neural stem cell proliferation by activating PVALB+ interneuron, as well as suppressed synaptic plasticity.

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