ラットのバルプロ酸発達期曝露による海馬神経新生障害に対するα-glycosyl isoquercitrinの保護効果

高嶋 和巳; 岡野 拡; 唐 倩; 高橋 康徳; 尾城 椋太; 菊地 聡美; 小栁 美穂子; 吉田 敏則; 渋谷 淳

doi:10.14869/toxpt.48.1.0_P-92

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-92

DOI https://doi.org/10.14869/toxpt.48.1.0_P-92

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Protective effects of α-glycosyl isoquercitrin on disruptive hippocampal neurogenesis caused by developmental exposure to valproic acid in rats

*Kazumi TAKASHIMA, Hiromu OKANO, Qian TANG, Yasunori TAKAHASHI, Ryota OJIRO, Satomi KIKUCHI, Mihoko KOYANAGI, Toshinori YOSHIDA, Makoto SHIBUTANI

Author information

*Kazumi TAKASHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Hiromu OKANO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Qian TANG
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Yasunori TAKAHASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Ryota OJIRO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Satomi KIKUCHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Mihoko KOYANAGI
San-Ei Gen F.F.I., Inc.
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

This study investigated the effect of continuous exposure to α-glycosyl isoquercitrin (AGIQ) as an antioxidant on a rat valproic acid (VPA)-induced autism model on hippocampal adult neurogenesis. Developmental VPA exposure suppressed hippocampal neurogenesis in male offspring targeting type-2a and type-3 neural progenitor cells in early postnatal life. AGIQ alleviated VPA-induced disruptive neurogenesis through amplification of neural stem/progenitor cells through increased reelin and neurotransmitter signals at the infant stage and increased synaptic plasticity at the adult stage.

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