Annual Meeting of the Japanese Society of Toxicology
The 48th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-93S
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e-Poster
Twenty-eight-day repeated oral exposure effect of aluminum chloride on adult hippocampal neurogenesis in postpubertal rats
*Saori SHIMIZUNatsuno MAEDAYasunori TAKAHASHIQian TANGRyota OJIROHiromu OKANOKazumi TAKASHIMASatomi KIKUCHIToshinori YOSHIDAMakoto SHIBUTANI
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Abstract

This study examined 28-day repeated oral exposure effect of aluminum chloride (AlCl3) on hippocampal neurogenesis in rats. Immunohistochemically, AlCl3 showed a decreasing trend in type-2a neural progenitor cells and an increase of GFAP+ astrocytes in the dentate gyrus hilus. Gene expression analysis suggested ameliorating responses of interneurons to suppressed neurogenesis. Enhancement of oxidative stress caused by suppression of antioxidant defense mechanisms and nitric oxide production may have induced the progenitor cell apoptosis and the increased reactivity of astrocytes.

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