ラットの胎生期lipopolysaccharide曝露誘発自閉症モデルに対するα-glycosyl isoquercitrinの改善効果

岡野 拡; 高嶋 和巳; 高橋 康徳; 尾城 椋太; 唐 倩; 菊地 聡美; 小栁 美穂子; 吉田 敏則; 渋谷 淳

doi:10.14869/toxpt.48.1.0_P-95

The 48th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-95

DOI https://doi.org/10.14869/toxpt.48.1.0_P-95

Conference information

Host: The Japanese Society of Toxicology

e-Poster

Ameliorating effects of α-glycosyl isoquercitrin on autism model induced by fetal LPS exposure in rats

*Hiromu OKANO, Kazumi TAKASHIMA, Yasunori TAKAHASHI, Ryota OJIRO, Qian TANG, Satomi KIKUCHI, Mihoko KOYANAGI, Toshinori YOSHIDA, Makoto SHIBUTANI

Author information

*Hiromu OKANO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Kazumi TAKASHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Yasunori TAKAHASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Ryota OJIRO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Qian TANG
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Satomi KIKUCHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Mihoko KOYANAGI
San-Ei Gen F.F.I., Inc.
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

Lipopolysaccharide (LPS) exposure induces neuroinflammation in animals. We examined the ameliorating effect of α-glycosyl isoquercitrin (AGIQ), an antioxidant, from the developmental stage on neural functions in an autism model produced by fetal LPS exposure in rats. On the weaning and/or adult stage, LPS-exposed offspring revealed abnormal behaviors and progressive disruption of hippocampal neurogenesis without accompanying neuroinflammation. AGIQ ameliorated the LPS-induced defects in neural functions in terms of behaviors and hippocampal neurogenesis.

Corresponding author

Register with J-STAGE for free!