Annual Meeting of the Japanese Society of Toxicology
The 48th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-94S
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e-Poster
Twenty-eight-day repeated oral exposure effect of lead acetate on adult hippocampal neurogenesis in postpubertal rats
*Natsuno MAEDASaori SHIMIZUYasunori TAKAHASHIQian TANGRyota OJIROHiromu OKANOKazumi TAKASHIMASatomi KIKUTIToshinori YOSHIDAMakoto SHIBUTANI
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Abstract

This study examined 28-day repeated oral exposure effect of lead acetate (PbAc) on hippocampal neurogenesis in rats. PbAc decreased TBR2+ cells but increased NeuN+ and ARC+ granule cells. PbAc also increased GFAP+ astrocytes and CALB2+ interneurons in the hilus. Mt1, Gsta5, Hmox1 and Il6 upregulated the expression. Thus, PbAc induced oxidative stress and neuroinflammation to inhibit differentiation into type-2b neural progenitor cells. Increases in granule cells and their ARC-mediated synaptic plasticity were suggested to be due to compensatory increased CALB2+ interneuron signaling.

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