Relationship between aromatase inhibitory activity in a new chemical entity and reproductive ability in rats

Abstract

We studied toxic relationship between aromatase inhibitory activity in a novel compound and its effect on reproductive ability in rats.

The compound was orally administered repeatedly to non-pregnant and pregnant rats for 14 or 16 days. Animals in high dose group showed their estrus cycle ceasing and decreased body weight gain. Plasma estradiol concentration decreased. Delayed delivery and increased neonatal mortality were observed.

These reproductive abnormality would depend on the decreased plasma estradiol concentration induced by the aromatase inhibitory activity in the compound.