Host: The Japanese Society of Toxicology
Activation of the nuclear receptor constitutive androstane receptor (CAR) induces hepatocyte proliferation and liver carcinogenesis in rodents. However, its mechanisms are still unknown. Besides, it is well known that CAR-dependent hepatocyte proliferation and liver tumorigenesis are not observed in humans. We have been investigating the molecular mechanism and the species differences, and found an involvement of yes-associated protein (YAP), which is known as a liver cancer inducer, in the CAR-induced hepatocyte proliferation in rodents. In this presentation, I will introduce our recent progress on this topic by focusing on the interaction between CAR and YAP.
