Identification of endpoints for androgen related-toxicity by using androgen overproducing transgenic mice and their application to toxicity tests

Abstract

Although androgens are important factors for formation of sex-specific reproductive organs, etc, many environmental chemicals with potential androgen antagonism have been found in recent years. However, there are some problems with toxicity tests for androgen-dependent toxicity, since knowledge of endpoints dependent on androgen action is still insufficient. To solve the problem, we established transgenic mice that overproduce androgens from the fetal period and attempted to identify the endpoints for androgen-dependent toxicity. In my talk, I will introduce the androgen-dependent endpoints we have found and propose a novel testing method for androgen-dependent toxicity.