Comparative toxicologenomics of PPARα ligands

Abstract

We have been analyzing Percellome data [1], which is the database of gene expression profiles of mice treated with various chemical compounds [1], to infer the mechanism of their toxicity. In this presentation, we will show the effects of estragole (a compound that belongs to phenylpropene suspected to be carcinogenicity in rodents) as a PPARα ligand based on the gene expression profiling, and the differences between the gene expression profiles of estragole and those of other PPARα ligands that have been analyzed in our previous study will be discussed.