Host: The Japanese Society of Toxicology
GeneChip data of mouse liver after a single oral gavage at 2, 4, 8, and 24 hours after dosing for 4 dose levels, triplicate, total of 48 samples, were compiled on 160 chemicals. And, now we added a new repeated dosing study data from a few chemicals by 14-day repeated dosing to all 48 mice followed by the single dose study protocol mentioned above. From the same sample, whole genome bisulfite analysis (WGBA) and ChIP-seq data against H3K4me3, H3K27me3, H3K27Ac, and H3K9me3 were obtained and analyzed for the effect of repeated dosing on DNA methylation and Histone modification. (Supported by Health and Labour Sciences Research Grant).
