Host: The Japanese Society of Toxicology
Lysine acylation of histones is a post-translational modification that regulates epigenetic gene expression. Acyl modification on lysine residues is induced by endogenous carboxylic acids such as fatty acids through in vivo chemical reactions. We are exposed daily to various exogenous carboxylic acids with foods, which may be added to lysine residues of target proteins including histone. In this presentation, we will introduce the regulation of gene expression by a food preservative sorbic acid through histone sorbylation and discuss possible influences of exposure to carboxylic acids in food from the perspective of lysine adduct exposome.
