Host: The Japanese Society of Toxicology
Exposome, which is a concept referring to total of lifetime exposure, is divided into three categories, general external, internal, and specific external. We have focused on electron acceptors, which generate reactive oxygen species (ROS), in the specific external exposome and have found that exposure to 9,10-phenanthraquinone (PQ), an electron acceptor, activates PTP1B/EGFR signaling through S-oxidation of PTP1B. This result lets us an assume that combined exposure to electron acceptors enhance ROS-mediated cellular responses such as EGFR signaling compare to individual exposure. Herein, we would like to introduce our research about PQ and discuss such a specific external exposome study.
