Host: The Japanese Society of Toxicology
Neurotoxicity is a major adverse effect pre-clinically and clinically. Among types of neurotoxicity, seizure is one of the most serious finding during the drug development process. Seizure evaluation is usually used to in vivo animal models. Recently, multi-electrode array (MEA) systems measuring the electrophysiological neuronal activities have attracted attention as useful for evaluation of seizure risk and alternatives to animal testing. Multiple parameters calculated from the electrophysiological responses are needed to evaluate the seizure of several seizure-induced compounds. In this section, we introduce evaluation methods for seizure risk using multiple parameters.
