Host: The Japanese Society of Toxicology
Alternative approaches to animal testing have been proposed under the movement of 3Rs. Various alternatives to eye-irritation tests have been developed in the field of ophthalmic research. Technologies mimicking in vivo condition, e.g., 3D in vitro culture and organ-on-chip system, have been reported in recent years. We have undertaken to develop in silico prediction or 3D and in vivo ocular genotoxicity evaluation methods. In this presentation, I will introduce recent knowledge and our challenges for in vitro and in silico approaches in ophthalmic drug safety.
