Host: The Japanese Society of Toxicology
Name : The 49th Annual Meeting of the Japanese Society of Toxicology
Date : June 30, 2022 - July 02, 2022
Humans obtain approximately 80% of their external information from vision, and therefore impairment of vision has a major impact on QOL. Considering the histological and functional characteristics of the eyes, drug-induced adverse effects on the eyes are often severe and/or unlikely to be reversible. Furthermore, the eye has been recently selected as the target tissue for new modalities of drugs, such as cell medicine and gene therapy, and as a result, ocular toxicity, which has characteristics different from those before, has also been reported. Taking these into account, understanding of the characteristics of the drug and considering the extrapolation of nonclinical data to humans are imperative to achieve an accurate nonclinical safety assessment and to predict the risk of ocular toxicity in humans.
Therefore, in this lecture, we will introduce how to interpret nonclinical study data for human safety based on the characteristics of drug and appropriate study design.
