Host: The Japanese Society of Toxicology
Name : The 49th Annual Meeting of the Japanese Society of Toxicology
Date : June 30, 2022 - July 02, 2022
The "food" ingested on a daily basis is located at the center of homeostasis, and its impact on life is enormous. However, among the functionalities of food, the actual state of bioregulatory functions related to health and diseases has not been clarified.
On the other hand, recent research has discovered that certain food ingredients rapidly react with proteins as covalent chemicals to create new innate immune antigens. In particular, it was found to be characteristic of antioxidants such as oxidized vitamin C and polyphenols, and to confer affinity with the innate immune molecule IgM natural antibody and complement C1q through protein modification (Chikazawa. et al., JBC, 2013; Furuhashi et al., Biochemistry, 2017; Hatasa et al., PLoS ONE, 2016; Yamaguchi et al., JBC, 2021). Interestingly, as a result of structural and specificity analysis of IgM antibody caused by these antioxidants, it has been revealed that they show strong cross-reactivity not only with antioxidant-modified proteins but also with proteins modified with acrolein, a harmful aldehyde compound. The multispecificity of IgM antibodies is presumed to be an acquired function and plays an important role as the immunological memory of certain antigens that act on multiplenon-causal antigens.
By clarifying the details of innate immune memory for adduct exposomes caused by food through analysis of such innate immune cells and natural antibodies, it is expected to elucidate the health function of food and lead to changes in lifestyles of the next generation including eating habits.
