Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
Non-clinical toxicity studies are compiled and stored as a final report. Data and discussion for toxicological findings are in-house assets and it is desirable that data are freely available for researchers. However, such information tended to depend on a researcher who conducted toxicity studies. Accordingly, it is not easy for researchers to personally explore past information especially studies in which they are not involved. Therefore, we constructed a database of in-house toxicity studies so that researchers can search the past study information. Applying constructed database, researchers, even if they didn’t involve in the study, can freely search the past data. In addition, since a list of compounds showing similar findings can be obtained by searching the annotation about toxicity findings, it would be useful for the construction of in-house compound sets applied to in vitro or in silico experiments, for example. In this presentation, we would like to introduce the outline of database construction of in-house toxicity studies, and also introduce actual use case that body weight and food consumption data from single dose study in rats were analyzed to lead to the evaluation criteria for estimation of the tolerability in repeated dose study as an example that the tacit knowledge of experienced researchers was transformed into explicit knowledge by cross-sectional analysis of the past studies registered in the database.
