臨床検査パラメータと関連臓器のリスト作成

松本 泉美; 中島 幹夫; 酒井 邦佳; 冨樫 裕子; 山本 雅克; 井上 裕基; 大島 毅; 西村 享平; 渡邊 真弓; 橋本 清弘; 山本 敏誠; 棚治 隆史; 川上 詔夫; 佐藤 玄; 本山 径子; 鈴木 睦

doi:10.14869/toxpt.50.1.0_P3-300

The 50th Annual Meeting of the Japanese Society of Toxicology

Session ID : P3-300

DOI https://doi.org/10.14869/toxpt.50.1.0_P3-300

Conference information

Host: The Japanese Society of Toxicology

Name : The 50th Annual Meeting of the Japanese Society of Toxicology

Date : June 19, 2023 - June 21, 2023

Poster Session

Creation of a list for clinical laboratory parameters and their associated organs

*Izumi MATSUMOTO, Mikio NAKAJIMA, Kuniyoshi SAKAI, Yuko TOGASHI, Masakatsu YAMAMOTO, Yuki INOUE, Tsuyoshi OSHIMA, Kyohei NISHIMURA, Mayumi WATANABE, Kiyohiro HASHIMOTO, Toshinobu YAMAMOTO, Takashi TANAHARU, Akio KAWAKAMI, Gen SATO, Keiko MOTOYAMA, Mutsumi SUZUKI

Author information

*Izumi MATSUMOTO
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Mikio NAKAJIMA
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Kuniyoshi SAKAI
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Yuko TOGASHI
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Masakatsu YAMAMOTO
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Yuki INOUE
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Tsuyoshi OSHIMA
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Kyohei NISHIMURA
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Mayumi WATANABE
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Kiyohiro HASHIMOTO
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Toshinobu YAMAMOTO
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Takashi TANAHARU
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Akio KAWAKAMI
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Gen SATO
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Keiko MOTOYAMA
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association
Mutsumi SUZUKI
Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceuticals Manufacturers Association

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

In non-clinical toxicity studies, laboratory tests are performed to clarify the effects of test articles on animals. A series of data that indicates the condition of the living body can be obtained by the tests. The obtained data is then used to interpret which parameters are associated with which organ changes and determine the toxicological significances. Experienced toxicologists may take this course of toxicological evaluation for granted. However, it is often difficult for less-experienced personnel to appropriately interpret changes in laboratory tests, as there is no comprehensive correspondence table between changed parameters and their corresponding organs available in place.

Therefore, we have created a list of laboratory tests parameters and their associated organs based on the measurement items and organs that listed in the Guidelines for Repeated Dose Toxicity Studies, incorporating additional information as necessary. Furthermore, the controlled terminology used in the Standard for the Exchange of Nonclinical Data (SEND) was also added to the table, considering the utilization of non-clinical data; which will enable the data scientist easily to refer to the parameters for each organ when visualizing the data and to facilitate communication with toxicologists.

Corresponding author

Register with J-STAGE for free!