Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
Allergic contact dermatitis is a delayed hypersensitivity reaction categorized as a Type IV allergy and involves various immune cells. It greatly affects the quality of daily life because contact with various chemicals is inevitable, therefore, evaluating the potential of skin sensitization is an important safety endpoint. Regarding the mechanism of skin sensitization, the adverse outcome pathway (AOP) has been developed and is relatively simple compared with other toxicological endpoints. Therefore, multiple in vitro or in silico test methods have been developed. To date, several in vitro test methods corresponding to each key event of the AOP have been listed in the OECD test guidelines, however, they are not stand-alone methods. Therefore, a combination of multiple in vitro and in silico models was developed and became the OECD test guideline TG497, as a first defined approach method in 2021. However, in vitro and in silico tests that can be used for the guideline are limited, and any potency prediction method, which is necessary for risk assessment, has not yet been established. Therefore, the OECD is currently conducting a study aimed at expanding TG497, and the current status will be introduced in my talk. In addition, the presenter has been working on the development of a potency prediction method for skin sensitization using machine learning, and will introduce the summary of the method. Furthermore, the development of the threshold of toxicological concern concept for skin sensitization will be introduced as an application example. In addition, the presenter will also introduce an attempt to predict a potency of Bandrovsky base, which is a trimer of the oxidation dye paraphenylenediamine using the prediction model. Lastly, a quantitative risk assessment case study of Bandrovsky base without animal testing will be introduced.
