Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
The growing evidence of gender-specific differences in drug efficacy and adverse reactions has prompted urgent action in biomedical research. Because the June 2015 statement (NO-OD-15-103) was issued, there has been a great deal of recent attention to sex difference research. Our laboratory focuses on biological sex differences in the cardiovascular field. For example, the risk of delayed ventricular repolarization (QT prolongation) and the incidence of drug-induced arrhythmias are known to be more prone to women than to men. This sex difference is associated with a longer QT interval in adult women than in men of the same age. Changes during puberty and the menstrual cycle suggest a sex hormone influence. We have shown from rodent experiments that the molecular mechanism may involve
NO-mediated sex hormone signaling in cardiomyocytes. However, the translational question of how to translate the results of such basic research into an interpretation of biological responses remains unresolved. Gender differences in anti-cancer drug-induced cardiotoxicity are also an issue to be addressed in the future. In this symposium, we would like to present our original approach and discuss future issues.
