Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
“Deductive toxicology" is a deductive approach to explain the toxicity of chemical substances to humans by collecting reproducible scientific findings on the toxicity. In accidental or incidental poisoning cases, it is impossible or extremely difficult to reproduce the exposure conditions, and "deductive toxicology" is effective in such cases. Based on this thinking method, we worked on the environmental toxicology of cadmium, lead, and methylmercury. Additionally, we pioneered "vascular toxicology" and obtained new findings useful for understanding not only vascular lesions but also organ toxicity of cadmium, lead, and methylmercury. On the other hand, we have conceived of a new molecular probe that takes advantage of the strong bioactivity of metals to analyze their biological functions. This is a new research strategy, bioorganometallics, utilizing organic-inorganic hybrid molecules. We started by investigating the cytotoxicity of organic-inorganic hybrid molecules to clarify their properties and mechanisms. Then, using the organic-inorganic hybrid molecules as molecular probes, we analyzed the mechanism underlying metallothionein induction in vascular endothelial cells, the mechanism of regulation of proteoglycan synthesis in endothelial cells, and the mechanism of synthesis of supersulfides in endothelial cells. I would like to confirm the development of the above studies, the new findings obtained, and the importance of free development of toxicological research, thereby contributing to the future of toxicology in some small way.
