Host: The Japanese Society of Toxicology
Name : The 50th Annual Meeting of the Japanese Society of Toxicology
Date : June 19, 2023 - June 21, 2023
Epigenetic regulation of gene expression determines cell fate and is involved in various life phenomena. On the other hand, this epigenetic genetic information can be influenced by diverse factors such as environment, and aberrant epigenetic changes are associated with various diseases, including cancers. Lysine acylation of histones is one of the molecular bases of epigenetic regulation. Some of these lysine acylations are caused by the addition of endogenous carboxylic acids such as fatty acids via acyl-CoA. We consume a variety of compounds daily through our diet, including carboxylic acids. These unintentionally ingested environment-derived carboxylic acids may modify histones and alter gene expression. Indeed, we found novel histone modifications induced by environment-derived carboxylic acids. In this presentation, we would like to introduce the hidden functions of environmental chemicals, focusing on the regulation of gene expression by histone modifications derived from sorbic acid, a food additive.
