Host: The Japanese Society of Toxicology
Name : The 51st Annual Meeting of the Japanese Society of Toxicology
Date : July 03, 2024 - July 05, 2024
Human individuals are constantly exposed to various exogenous/endogenous electrophilic compounds, which readily react with proteins to form a variety of covalent adducts. The covalent modifications of proteins are thought to be involved in various pathological processes. Oxidized lipids such as reactive aldehydes are endogenous electrophiles that react with nucleophilic amino acids, such as lysine, histidine, and cysteine residues, resulting in the formation of covalent adducts. Because of the diversity of oxidized lipids, a variety of adducts might be formed in proteins. Recently, the concept of “protein adductome” has been proposed to represent the totality of covalent adducts bound to protein. In the research of covalent adducts in proteins, mass spectrometry is a powerful tool for their detection and quantification. Based on these backgrounds, we have been conducting adductome analysis using mass spectrometry to understand the complex adducts in protein. In this presentation, we would like to talk about the adductome analysis of oxidized low-density lipoprotein.
