Abstract
Particle pollution is known to induce allergic inflammation in the lungs. These particles function as adjuvant and trigger allergic immune responses characterized by the induction of IgE and activation of eosinophils. However, the underlying mechanisms by which inorganic particles induce allergic immune responses are still unclear. In this study, we are focusing on the role of alveolar macrophages and are investigating the effect of inorganic particles on the activation. So far, our research has shown that inflammatory particles such as aluminum salt (alum) and silica stimulate alveolar macrophages to release IL-1alpha.The release of IL-1alpha is mediated by cell death, specifically through a dead cell factor known as a damage-associated molecular pattern (DAMP). Interestingly, despite both being aluminum, aluminum oxide particles did not induce cell death and IL-1alpha, indicating that the chemical properties of particles play a role in the function of alveolar macrophages. In this symposium, we will discuss the impact of particle chemical properties on immune responses.
