Tokyo Women's Medical University Journal
Online ISSN : 2432-6186

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Secondary Publication: SARS-CoV-2 and Immunological Response
Hidehito KatoNaoko Yanagisawa
著者情報
キーワード: spike protein, ACE2, ADE, BCG, HLA
ジャーナル オープンアクセス 早期公開

論文ID: 2021001

この記事には本公開記事があります。
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Viruses require the host cellular machinery for protein translation and replication. Upon proliferation, virions damage cells and are released from the infected cells before infecting other cells. Acute inflammation occurs when host cells are damaged by infection. The cell receptors to which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) binds, are widely distributed compared to those for other viruses, thereby resulting in various symptoms such as rhinitis, pneumonia, and enteritis. In general, RNA viruses, including SARS-CoV-2, exhibit a high frequency of gene mutations. Antigenic modulation due to genetic mutations of the spike protein causes cytokine storms because of strong activation of the innate immune system, similar to the phenomenon previously observed in highly pathogenic avian influenza. The proportion of severely ill patients due to coronavirus disease 2019 (COVID-19) varies from country to country, and factors that are responsible for the severity of the disease include antibody-dependent enhancement (ADE), Bacillus Calmette-Guérin (BCG) vaccination, and human leukocyte antigen (HLA) type. ADE and HLA types may also influence the protective effect of immunity, including its vaccine response against SARS-CoV-2.

This report is a secondary publication of our previous review report "Tokyo Wom Med Univ 91: 2-10, 2021."

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© 2021 Society of Tokyo Women's Medical University

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