Cytogenetic findings in a case of pigmented villonodular synovitis and a review of the literature

Abstract

　Cytogenetic studies of pigmented villonodular synovitis (PVS), a rare tumor−like synovitis of adults, are few. A characteristic anomaly has not yet been identified for this pathology. In this study, cytogenetic analysis of a recurrent PVS of a 51−year−old female revealed the following clonal abnormalities: trisomies 5 and 7. These findings support that some cases of PVS represent clonal neoplastic proliferations. The literature data about cytogenetic aberrations in PVS and its related pathology, are reviewed.