Abstract
It was reported by Higashi that hypervitaminosis A tended to be overestimated since oxidized or polymerized products of vitamin A might be able to cause hypervitaminosis. This paper presents the investigation on hypervitaminosis A in rats using synthetic crystalline vitamin A acetate. The result indicated that the hypervitaminosis was recognized in an administration of 10,000 I.U. of the vitamin per day, and a severe disorder in 30,000 I.U.. The effect of the presence of vitamin E on the hypervitaminosis was not recognized.
