Abstract
Brain γ-aminobutyric acid was examined during the running fit. It is reduced during the 2-methyl-4-amino-5-hydroxymethylpyrimidine induced seizure and this reduction is already apparent prior to the onset of the seizure so is not a result of the running fit. No reduction is found when the seizure is suppressed by the concomitant administration of pyridoxine or 2-methyl-4-amino-5-aminomethylpyrimidine. The γ-aminobutyric acid is also markedly reduced in the isonicotinic acid hydrazide induced running fit. When pyridoxine is administered at the same time, the seizure occurs earlier and the reduction in γ-aminobutyric acid also becomes apparent sooner. It is suggested that the cause of the running fit and the reduction in γ-aminobutyric acid are closely related.
