STUDIES ON SUBSTANCES OF THE TOXOPYRIMIDINE GROUP : (XV) THE SUPPRESSIVE EFFECT OF GAMMA-AMINOBUTYRIC ACID AND BETA-HYDROXY-GAMMA-AMINOBUTYRIC ACID ON THE RUNNING FIT

Abstract

Experiments were conducted on the suppression of the running fit by γ-aminobutyric acid and β-hydroxy-γ-aminobutyric acid. The seizure was not prevented by γ-aminobutyric acid. It is believed that the γ-aminobutyric acid which is administered does not reach the brain effectively. The seizure was regularly inhibited by β-hydroxy-γ-aminobutyric acid. It is suggested that γ-aminobutyric acid is oxidized to β-hydroxy-γ-aminobutyric acid in the brain.