Abstract
The anticonvulsive and stimulation suppressing action of β-hydroxy-γ-aminobutyric acid was examined and it was found that it possessed a marked convulsion suppressing action against centrally acting agents as cardiazol, camphor, procaine hydrochloride and procaine penicillin in oil. No action however, was noted against strychnine. A marked depressive action was also noted against stimulating agents of the amphetamine series as Philopon (β-phenylisopropylmethylamine) and Zedrin (β-phenylisopropylamine). It is suggested that β-hydroxy-γ-aminobutyric acid has a physiological depressing action in the brain towards convulsions and excited states.
